Proton therapy fails to improve survival in advanced liver cancer trial

· Science

Initial results of the NRG Oncology NRG-GI003 trial show proton therapy did not improve overall survival compared with photon therapy in patients with advanced hepatocellular carcinoma. The trial was released for reporting at a planned interim analysis.

Why it matters：Hepatocellular carcinoma is one of the most common and deadly cancers worldwide, and the result challenges assumptions about whether proton therapy's higher cost translates into better outcomes.

Key points

  • Trial compared proton and photon therapy in advanced hepatocellular carcinoma.
  • Primary endpoint was overall survival; proton therapy did not improve it.
  • Results released at a planned interim analysis.

Sources (original reporting)

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